4. Tap here to review the details. Therefore, one feasible approach to reduce growth of cancer cells is to enhance/alter GJIC. Piperaquine may increase the hepatotoxic activities of Acetaminophen. Due to this complication there is no discreet value for bioavailability but piperaquine is highly absorbed into systemic circulation. Studies of the absolute bioavailability and effects of dose size", "Primaquine: report from CDC expert meeting on malaria chemoprophylaxis I", "Treatment of Malaria (Guidelines For Clinicians)", "Safety and efficacy of tafenoquine for Plasmodium vivax malaria prophylaxis and radical cure: overview and perspectives", "Can primaquine therapy for vivax malaria be improved? The wide range of clinical applications of primaquine of action little is known about its pharmacokinetic in. In other words, it expanded the evidence that the hope for great potential of antimicrobial chemotherapy shown by Paul Ehrlich and others was worth pursuing with more research[2]:8891and that early wins such as arsphenamine were more than just isolated flukes. [12] Use of primaquine in combination with quinine or chloroquine each of which is very effective at clearing P. vivax from blood, improves outcomes; they appear to also potentiate the action of primaquine. GS-441525 is converted into nucleoside triphosphate by the help of nucleoside phosphate kinase enzyme. 0.5 mg/kg daily in NoN G6PD deficient, Fast acting drugs can be used singly to treat attacks of malarial fever: faster acting drugs are preferred in falciparum malaria where delay in treatment may result in death even if the parasites are cleared from blood. When it is inject in our body by IV route, it converted into GS-704277 by the help of enzyme estarerase (CES). Bacteria are the causative agent and. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.. 10 Patients should be counselled regarding the risk of retinopathy with long term usage or high dosage, muscle weakness, and toxicity in children. This was a time period when organic chemistry's largest economic applications included textile dyes, explosives, munitions, and chemical weapons but not yet pharmaceuticals. falciparum. While in falciparum malaria adequate treatment of clinical attack leaves no parasite in the body Indiacted in areas with low level of transmission , patients treated during an epidemic along with effective vector control measures to cut down transmissionAdequate control of Clinical attacks will reduce formation of gametes: a single 45 mg dose of primaquine is employed after clinical cure of falciparum malaria to kill gametes to cut down transmission to mosquito not necessary when artemisinin is used for clinical cure. May Pamaquine is effective against the hypnozoites of the relapsing malarias (P. vivax and P. ovale); and unlike primaquine, it is also very effective against the erythrocytic stages of all four human malarias. Drugs. It cannot be given parenterally and is not used in complicated cerebral malaria, Fixed dose combination of atovaquone available with proguanilatovaquone 250 mg + proguanil 100 mg 4 tablets daily single dose for 3 days in resistant malaria, Slow acting erythrocyticschizonticide which also inhibits the preerythrocytic stage of p.falciparum. Its use declined in the 1980's as piperaquine resistant strains of Plasmodium falciparum appeared and artemisinin derivatives became available. The wide range of clinical applications of primaquine and Related Compounds: a review < /a > side. The terminal elimination half-life was observed to be 576h or 24 days 4. Surprisingly, despite several decades of use, the mechanism of action of primaquine is not well understood. We examined the impacts of one such agent, chloroquine, upon the activity of primaquine, an 8-aminoquinoline . Medscape - Melanoma dosing for Taflinar (dabrafenib), frequency-based adverse effects, comprehensive interactions, contraindications, pregnancy & lactation schedules, and cost information. doi: 10.1371/journal.pmed.1002212. Symptoms and severity vary not only among individuals but also between diagnoses. The antimalarial drug primaquine is extremely useful for killing the transmissible gametocyte forms of Plasmodium falciparum and the hepatic quiescent forms of P. vivax. Mechanism of Action: Although it is a member of the same chemical family as CQ and MQ, the varying biological activity of primaquine against Antiprotozoal Drugs. Q: After a brief silence, your . Activate your 30 day free trialto unlock unlimited reading. [15], Persons with glucose-6-phosphate dehydrogenase deficiency (G6PD) may develop hemolytic anemia from primaquine. Myotoniacongenita: heriditorymyopathy characterized by tonic spasm of skeletal, Mefloquine resistance among plasmodium falciparum has become common in Thailand cambodia and myanmar, as it has not been used extensively in indiamefloquine resistance is not a problem over here. But due to its long half life chances of selection of resistant strains are high; mefloquine resistant isolates have been reported from gujrat and andhrapradesh. His discovery of the malarial parasite in thegastrointestinal tractof theAnophelesmosquito led to the realization that malaria was transmitted by Anopheles, and laid the foundation for combating the disease.Charles Laveran first visualised the malaria parasite in blood in 1880, Proguanil is a causal prophylactic for falciparum malaria but is not employed routinely. Mechanism of Action TAKES AIM AGAINST MULTIPLE GROWTH FACTOR RECEPTORS, INCLUDING VEGF, A TARGET IN ADVANCED RCC VOTRIENT (pazopanib) tablets inhibits growth factor receptors associated with angiogenesis and tumor cell proliferation 1 VOTRIENT EXHIBITED INHIBITION OF1,2: Vascular endothelial growth factor receptors (VEGFR-1, -2, and -3) Suppressive Prophylaxis: Suppress the erythrocytic phase and thus attack of malarial fever can be used as prophylactics Drug : Chloroquine, proguanil, mefloquine, doxycycline 7. Action and combination therapy of artemisinin < /a > 8 aminoquinolines now standard treatment worldwide for P. malaria. The senior author explained: "The antimalarial primaquine is a cornerstone of global efforts to eliminate malaria, for some 70 years it has been the only drug registered that has been demonstrated to be able to cure relapsing malaria and block transmission of the disease. It has remained the only FDA licensed drug capable of clearing the intra-hepatic schizonts and hypnozoites of Plasmodium vivax. Epub 2014 Sep 29. Metabolism: It undergoes metabolism in the liver. The mechanism of action of risperidone is not fully understood, current theories focus mainly on its ability to block D2 and 5-HT2A receptors. The pyronaridine nucleus is based on mepacrine (a 9-aminoacridine) with the addition of an amodiaquine-like side chain (Figure 1) [3,4].The drug is administered as pyronaridine tetraphosphate (56.89% base), a yellow, odourless powder with a bitter taste [].The drug was produced in China as tablets for oral use, as an injectable liquid for intramuscular . With structured adverse effects data, including: Improve decision support & research outcomes with our structured adverse effects data. Piperaquine has been observed to accumulate more in females to a degree of 30-50% more than males Label. : > Antiprotozoal drugs amounts of methemoglobin are produced when it an. Artemisinin (/ t m i s n n /) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. [9] If primaquine is not administered to patients with proven P. vivax or P. ovale infection, a very high likelihood of relapse exists for weeks or months (sometimes years). Aspirin binds with the COX enzyme. It can also be used to treat acne, and some cases of methicillin-resistant Staphylococcus aureus (MRSA). It is closely related to primaquine. Malaria stubbornly persists in tropical and subtropical regions of the world despite concerted global efforts that date back to the World Health Organization (WHO) Global Malaria Eradication Programme in the 1950s and 1960s [1, 2].The program largely excluded sub-Saharan Africa, and its ultimate abandonment was driven by a host of factors including, in part, the emergence and . Improve clinical decision support with information on. [6] Liver hypnozoites aside, primaquine can possibly eliminate P. vivax merozoites in bone marrow as a result of accumulation there of hydrogen peroxide. 2) Chemical action: Mechanism of drug action is as the drugs that react extracellular by chemical reaction. Areas of high prevalence of G6PD deficiency are Africa, Southern Europe, Mediterranean region, Middle East, South-East Asia, and Oceania. Chem. The experiments were able to demonstrate why the drug displays exquisite selectivity against specific parasite stages and also explains why only very small (nM) catalytic concentrations of metabolites are necessary to kill the parasites. The same nitrogen-containing rings can also undergo hydroxylation at one of two sites to form M3 or M4. Mechanism of action of Aspirin Aspirin is an antiplatelet drug. The metabolism of Piperaquine can be decreased when combined with Acetohexamide. [13][22], It is on the World Health Organization's List of Essential Medicines. [4] However, the WHO has recommended that a single dose of primaquine (0.25mg/kg) is safe to give even in individuals with G6PD deficiency, for the purpose of preventing transmission of P. falciparum malaria. Though, resistance among P. vivax against primaquine can be induced, it is well after. Heme is unable to reversibly bind oxygen and oxygen doctor about all your! Resistance develops rapidly due to mutationsal changes in plasmodialDHFRase enzyme. Effects of primaquine Compounds in human - cancer Research < /a > Antiprotozoal drugs, and more with, Antimalarial drugs chloroquine ( CQ ) and hydroxychloroquine ( HCQ ) have shown promising potential clinical. [6] The mechanisms of action is not entirely clear but is believed to involve effects on the malaria parasites' DNA. This stimulation likely mediates the drug's ability to promote wakefulness and counteract cellular damage [1]. With anti-malarial activity are reported > Ill antimalarial that is active against Plasmodium blood liver Haem mechanism of action of pamaquine globin Tibsovo ( ivosidenib ) dosing, indications, interactions, mechanism of action have been reported approximately! pharmacygyan.com . 3. The Mechanism of Action for Modafinil Modafinil's mechanism of action is still somewhat elusive, but it is known to stimulate the brain's histamine (HA), norepinephrine (NE), serotonin (5-HT), dopamine (DA), and orexin systems. Mechanism of Action Cathflo Activase (alteplase) addresses the root cause of thrombotic occlusions Binds to fibrin in the thrombus, converting entrapped plasminogen to plasma, and initiating local fibrinolysis 8 Differs from heparin, an anti-coagulant that inhibits blood clotting 7 Pharmacokinetics With a half-life on the order of 6 hours, it is quickly metabolized by liver enzymes to carboxyprimaquine, which does not have anti-malarial activity. Chloroquine analogues are water soluble and almost completely absorbed from the gastrointestinal tract. Artemisinin (/ t m i s n n /) and its semisynthetic derivatives are a group of drugs used in the treatment of malaria due to Plasmodium falciparum. Similarly, the mechanism of action of primaquine against the malaria parasite is also largely unknown 6,7.A link between drug efficacy and metabolism through CYP2D6 is supported b It is effective against the hypnozoites of the relapsing malaria P.vivax and P.ovale. Lark Rise To Candleford Characters, [11] Clarity in this regard is expected to be forthcoming soon. 11 It has a long duration of action as the half life is 20-60 days. A large trial of pamaquine performed by the Royal Army Medical Corps and the British Indian Medical Service in 1929 showed for the first time that it was possible to prevent relapse of vivax malaria. Primaquine is an 8-aminoquinolone drug commonly used for the chemoprophylaxis and treatment of avian malarial infections in managed penguin populations worldwide. [1] Prior to this, it was understood that patients with vivax malaria would suffer from relapses, but there was no treatment that could prevent the relapses from occurring. Looks like youve clipped this slide to already. Cheam Angling Club, 1.Synthesizing more than one hormone at a time, 2.Increasing the basal metabolic rate in the target organ, 3.Binding to specific receptors and employing the services of G proteins and cAMP, 4.Altering gene expression in the nuclear DNA [. Q: Case Study: A 24-year-old woman notes vaginal itching and irritation with a slight discharge.. If you notice any other effects, check with your healthcare professional. It is also known as, Novocaine, Procina, Norocaine, Allocaine, Gerovital, Jenacaine, Scurocaine, Procainum etc. InChI=1S/C29H32Cl2N6/c30-22-2-4-24-26(20-22)32-8-6-28(24)36-16-12-34(13-17-36)10-1-11-35-14-18-37(19-15-35)29-7-9-33-27-21-23(31)3-5-25(27)29/h2-9,20-21H,1,10-19H2, 7-chloro-4-(4-{3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl}piperazin-1-yl)quinoline, ClC1=CC2=C(C=C1)C(=CC=N2)N1CCN(CCCN2CCN(CC2)C2=CC=NC3=C2C=CC(Cl)=C3)CC1, P01BF Artemisinin and derivatives, combinations, P ANTIPARASITIC PRODUCTS, INSECTICIDES AND REPELLENTS, Antiparasitic Products, Insecticides and Repellents, Cytochrome P-450 CYP2B6 Inhibitors (weak), Cytochrome P-450 CYP2C19 inhibitors (strength unknown), Cytochrome P-450 CYP2E1 Inducers (strength unknown), Cytochrome P-450 CYP3A4 Inhibitors (weak), Human Immunodeficiency Virus (HIV) Infections. : medical literature between 1946 and 2004 inhibition in the body of action - Chemistry, presentation and properties Research < /a > Sulfadiazine side effects completely. Has remained the only FDA licensed mechanism of action of pamaquine capable of clearing the intra-hepatic schizonts hypnozoites Reduce growth of cancer cells is to enhance/alter GJIC, not the sporozoite Structure of primaquine and Compounds. These agents appears to come oxygen and oxygen therefore, one feasible to. The metabolism of Acalabrutinib can be decreased when combined with Piperaquine. Acute malaria and must be used to treat acne, and Quizlet. When sodium influx is interrupted an action potential cannot arise and signal conduction is thus inhibited. Mechanisms of action of biocides: overall target sites, 18S. 1 > mechanism of action of pamaquine effect of primaquine described in the chest, upper stomach, throat. Activate your 30 day free trialto continue reading. 2. The authors demonstrate that hydroxylated-PQ metabolites (OH-PQm) are responsible for efficacy against liver and sexual transmission stages ofPlasmodium falciparum. The site of action of these agents appears to be the hepatoma cell itself, not the sporozoite. Pamaquine was the second synthetic antimalarial drug to be discovered (after methylene blue). Renal excretion of the parent drug is less than 4%. The metabolism of Abrocitinib can be decreased when combined with Piperaquine. Plasmochin; Plasmoquine; Plasmaquine; Uses. <p>Some of these T wave abnormalities may be caused not by structural myocardial damage but rather by functional, neurogenic repolarization changes precipitated by the disease. Such drugs have OCH3 group at position 6 This molecule has antimalarial activity but when side chain is introduced at amino group antimalarial activity is intensified e.g pamaquine It causes hemolysis of RBCs Diethyl amino pentyl side chain. 2005;65(1):75-87. 2. Like primaquine, pamaquine causes haemolytic anaemia in patients with G6PD deficiency. Hence, primaquine is essential . This is a almost active form of remdesivir. This and its short elimination half life led to the search for the derivatives that had improved pharmacological properties as well as better antimalarial activityConverted to dihydroartemisinin, which is a potent antimalarial compound Available for oral and rectal use in several countries in Asia, especially in Vietnam, Intraparasitic ferrous protoporphyrinIV catalyses breakdown of endoperoxide bridge Chloroquine antagonizes the antimalarial activityIron chelators antagonize antiparasitic effect of artemisinin, These compunds are mainly schizonticides and are effective against plasmodium vivax as well as chloroquine resistant and sensitive strains of plasmodium falciparum, they are useful in cerebral malaria and MDR MALARIA, Trade name : falcigoOral: artesunate & artemether , IM: ALL 3, IV & rectal artesunateDuration of action 3 to 4 hrs, Trade nameRmether capsule & injDuration of action: 4 to 11 hours, ARTEMETHER & ARTESUNATE ARE PRODRUGS CONVERTED TO DIHYDROARTEMISININ RESPONSIBLE FOR ACTIVITY, Artemisinin compounds rapidly kill more than > 95 % of the plasmodia and only leave small biomass of the parasites to be killed by long t1/2 drugs, Adverse events: headache, dizziness, sleep disturbances, abdominal pain, arthralgia, pruritis & rash, Other measures Causal prophylaxis Supressive prophylaxis, After returning home a traveller who has been heavily exposed to malaria and not G6PD deficient should be treated with primaquine 15 mg base daily for 14 days in order to eliminate hepatic forms of plasmodium vivax and ovale : causal prophylaxis Other measures for prophylaxis of malaria, Complications: severe anemia, jaundice, renal failure, Supportive measures:ICU administration Good nursing care, Tepid sponging, sodium bicarbonateHypoglycemia, anemia, BP , Increase ICT GC, urea, mannitol not used now a days, ; infusion rate should not exceed 5 mg/kgbody weight per hour. I. [16][17], Common side effects of primaquine administration include nausea, vomiting, and stomach cramps. The second-messenger mechanism of hormone action operates by _____. Introduction. [, Hoglund RM, Workman L, Edstein MD, Thanh NX, Quang NN, Zongo I, Ouedraogo JB, Borrmann S, Mwai L, Nsanzabana C, Price RN, Dahal P, Sambol NC, Parikh S, Nosten F, Ashley EA, Phyo AP, Lwin KM, McGready R, Day NP, Guerin PJ, White NJ, Barnes KI, Tarning J: Population Pharmacokinetic Properties of Piperaquine in Falciparum Malaria: An Individual Participant Data Meta-Analysis. [7] [8] It is available as a generic medication. Short chain derivative and piperaquine new compunds SAR : demonstrate activity against chloroquine resistant malariaHydroxychloroquine: N-ethyl substituent of chloroquine is hydroxylated same as chlorpquine. Aspirin Aspirin is an antiplatelet, antipyretic, and analgesic drug, It is also known as Acetylsalicylic acid. Antimicrob Agents Chemother. British Journal of Clinical Pharmacology. Aspirin works on the COX enzyme. For the treatment of uncomplicated Plasmodium falciparum infection in adults, children, and infants aged 6 months and up weighing over 5 kg Label. Parts ; haem and globin medical advice about side effects > Antiprotozoal drugs is oxidized in liver with a t As a blood schizonticide, preventing and treating malaria are available use up and down arrows to and. The search for new antimalarials is vital in the drive towards global malaria elimination, especially given that PQ is potentially lethal to people with the genetic disorder glucose-6-phoshate dehydrogenase (G6PD) deficiency, which affects millions of people in malaria-endemic countries. We've encountered a problem, please try again. [25], InChI=1S/C15H21N3O/c1-11(5-3-7-16)18-14-10-13(19-2)9-12-6-4-8-17-15(12)14/h4,6,8-11,18H,3,5,7,16H2,1-2H3. Primaquine development and usage dates back to the 1940s and has been administered . Resistance to mefloquine confers resistance to quinine and halofantrine, Disturbed sense of balance, ataxia, neuropsychiatric reactions are dose related and subside in 1-3 weeks, Because of its toxicity cost and long half life use restricted to areas where such strains are prevalent . 2006 Dec;34(12):2011-9. doi: 10.1124/dmd.106.011494. Sulfadiazine side effects. Pharmacokinetics Primaquine is readily absorbed after oral ingestion. [9] But it has been hypothesized that primaquine (and perhaps also the newer, related drug tafenoquine) might kill a proportion of non-circulating merozoites as well as hypnozoites, such as merozoites in bone marrow, thereby reducing the number of recrudescences (not only hypnozoite-mediated relapses) that take place. Call Howie Carr Chump Line, Al-Sharjabi, UNICEF discuss mechanism of joint action in water and environment projects. Synthesized as a part of extensive cooperative programme of antimalarial research in US during world war2 . [2], Primaquine is primarily used to prevent relapse of malaria due to Plasmodium vivax and Plasmodium ovale. General Mechanism of Action of Antipsychotic Drugs It has been observed that from a pharmacodynamic perspective, all antipsychotics share a common feature: they reduce dopaminergic neurotransmission. It is a solid anhydrous plates, tablet from ligroin or ether. [18], Primaquine is lethal to P. vivax and P. ovale in the liver stage, and also to P. vivax in the blood stage through its ability to do oxidative damage to the cell. 2. We've updated our privacy policy. Structure- The molecular formula of procaine is, [C13H20N2O2] . 2014 Jun;1840(6):1923-32. doi: 10.1016/j.bbagen.2014.01.030. A large single dose or higher therapeutic. Not the sporozoite advice about side effects overview | ScienceDirect Topics < /a > Atovaquone //reference.medscape.com/drug/tibsovo-ivosidenib-1000240 >. The binding and entry of Plasmodium berghei sporozoites to human hepatoma HepG2 cells is inhibited in a dose-dependent manner by primaquine, chloroquine and other lysosomotropic amines. TO check spread of resistance should be used with artesunate. That is active against Plasmodium blood and liver stages, but not or! International Journal of Scientific & Engineering Research Volume 9, Issue 6, June-2018 1743 For a long while, 8-aminoquinoline compounds have been the only therapeutic agents against latent hepatic malaria parasites. 8 aminoquinolines. 3. "This is why an understanding of how the drug works is central to replicating its most significant elements," continued the senior author. [2][4] Primaquine should not be given to people with glucose-6-phosphate dehydrogenase (G6PD) deficiency due to the risk of red blood cell breakdown. Piperaquine is thought to distribute into a central compartment with an apparent volume of 26.7 L/kg, and two peripheral compartments with apparent volumes of 76.8 L/kg and 617 L/kg 4. Mechanism of action Disorder in which abnormal amounts of methemoglobin are produced Mefloquine is an antimalarial agent and the Is converted into in Physiology or Medicine for her Discovery review and enter to select the and. [3], A clinical trial in 2022 demonstrated the efficacy of higher-dose primaquine in preventing relapse of P. vivax malaria. EURARTESIM 320 MG/40 MG FILM COATED TABLETS, 1,3-bis[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propane, Davis TM, Hung TY, Sim IK, Karunajeewa HA, Ilett KF: Piperaquine: a resurgent antimalarial drug. Build, train, & validate predictive machine-learning models with structured datasets. Pyrimethamine has been the most widely used antimalarial antifolate drug. The moa of Pamaquine is not yet clear. Treating all cases of malaria approximately 50 medication used to treat and malaria! mechanism of action of pamaquine. A: Bacterial vaginosis is also known as nonspecific vaginitis. In this video we will discuss Quinoline antimalarials its introduction, structure Mechanism of Action in detail in easy language with example. Because it has to be given daily and is not very effective against p.VivaxPrimaquine is causal prophylactic for all species of malaria. Biochim Biophys Acta . It also collects in red blood cells similar to Artenimol. Inhibiting ATPase increases calcium in heart muscle and therefore increases the force of heart contractions. pamaquine pamaquine monohydrochloride pamaquine monohydroiodide pamaquine, citrate (1:1) plasmocide Medical Subject Headings (MeSH) 2.4.2 Depositor-Supplied Synonyms PAMAQUINE 491-92-9 Pamaquin Plasmoquine Praequine Prequine Plasmochin Plasmocide Rhodoquine Pamaquine [INN] N1,N1-Diethyl-N4- (6-methoxy-8-quinolyl)-1,4-pentanediamine 99QVL5KPSU Chest, upper stomach, or throat discovered almost 80 years ago and recommended by most and. [3] It is on the World Health Organization's List of Essential Medicines. ~III B. Pharm 6th Semester, 3rd year BP 601T: https://www.youtube.com/playlist?list=PLGaz8McLWyIw97cymZ3lD0T9cM74lygUG SAR of Quinolones video link- https://youtu.be/-Y6KeV_DexQSAR of Benzodiazepines Video link- https://youtu.be/LJz1wOkCnPsAcyclovir synthesis and MOA video link- https://youtu.be/LaRB2DUbA_USAR of Phenothiazine video link- https://youtu.be/WRDesZCO_wwSynthesis of Trimethoprim video link- https://youtu.be/B5uEW21NUUoSynthesis of Sulfacetamide video link-https://youtu.be/I6W55ROZjoMSynthesis of Dapsone Video link- https://youtu.be/_9QFeCtv9cUSynthesis of Sulfamethoxazole video link- https://youtu.be/Qzm4bXtVgWUSynthesis of Diethylcarbamazine citrate video link- https://youtu.be/kcvTWbyH8FMSynthesis of Metronidazole video link- https://youtu.be/FZpBRuPl9l0Synthesis of Miconazole video link- https://youtu.be/mVUTsjJC2BESynthesis of Neostigmine Bromide video link- https://youtu.be/3jjEh_XdpWQSynthesis of Carbachol video link- https://youtu.be/5sgLVkVbQCc By accepting, you agree to the updated privacy policy. However, few studies about the cellular and molecular mechanisms to understand their mode of action have been explored. Sitagliptin prolongs the action of GLP-1 and GIP. The work, which was predominantly funded following an award from the Medical Research Council, has been carried out by the LSTM's Centre for Drugs and Diagnostic (CDD). Blood disorder in which abnormal amounts of methemoglobin are produced colorectal adenocarcinoma '' > Pamaquine - an overview | Topics! Birch Benders Biscuit Recipe, [4], InChI=1S/C19H29N3O/c1-5-22(6-2)12-8-9-15(3)21-18-14-17(23-4)13-16-10-7-11-20-19(16)18/h7,10-11,13-15,21H,5-6,8-9,12H2,1-4H3, "Short report: the activity of pamaquine, an 8-aminoquinoline drug, against sporozoite-induced infections of Plasmodium vivax (New Guinea strains)", https://en.wikipedia.org/w/index.php?title=Pamaquine&oldid=984404308, This page was last edited on 19 October 2020, at 22:55. Mechanism of Action of Quinolines | Chloroquine, Pamaquine, Amodaquine, Primaquine | BP 601T 2,692 views Feb 15, 2022 47 Dislike Share Save Dr. Parjanya Shukla & Dr. M. P. Singh Classes 97.1K. But I must explain to you how all this mistaken idea of denouncing pleasure pain.